Excess weight gain, especially when associated with increased visceral adiposity, is a major cause of hypertension, accounting for 65% to 75% of the risk for human primary (essential) hypertension. Increased renal tubular Na reabsorption impairs pressure natriuresis and plays an important role in initiating obesity hypertension.
The mediators of abnormal kidney function and increased blood pressure during development of obesity hypertension include , physical compression of the kidneys by fat in and around the kidneys, , activation of the renin–angiotensin–aldosterone system, and increased sympathetic nervous system activity. Activation of the renin–angiotensin–aldosterone system is likely due, in part, to renal compression, as well as sympathetic nervous system activation. However, obesity also causes mineralocorticoid receptor activation independent of aldosterone or angiotensin II.
The mechanisms for sympathetic nervous system activation in obesity have not been fully elucidated but may require leptin and activation of the brain melanocortin system. With prolonged obesity and development of target organ injury, especially renal injury, obesity-associated hypertension becomes more difficult to control, often requiring multiple antihypertensive drugs and treatment of other risk factors, including dyslipidemia, insulin resistance and diabetes mellitus, and inflammation. Unless effective antiobesity drugs as well as best fat burning supplements, slimming tablets, fat burning pills, natural weight loss pills and weight loss supplements are developed, the effect of obesity on hypertension and related cardiovascular, renal and metabolic disorders is likely to become even more important in the future as the prevalence of obesity continues to increase.
Researchers have found that chromium administered by mouth lowered high blood pressure levels, and increase fiber intake will contribute to the prevention of hypertension so Cro-roch is the best way to lose weight and maintain blood pressure
Losing weight and weight management are the ideal solution to get the patient out the diseases viscous cycle.