Obesity& Immune Diseases

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Obesity plays major role in triggering autoimmune diseases

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Obesity plays an important role in causing autoimmune diseases.

Autoimmune diseases like Crohn’s Disease and multiple sclerosis, in which the immune system attacks its own body rather than bacteria and illnesses, affect 5-20% of the global community. Recent studies in autoimmunity reviews have found that obesity has a major role in causing autoimmune diseases.

ِِAccording to those researches, obesity leads to a breakdown of the body’s protective self-tolerance so creating appropriate environment for autoimmune diseases, and generates a pro-inflammatory environment likely to worsen the disease’s progression and impede its therapy.

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“According to the World Health Organization, approximately 35% of the global community is overweight or obese, and more than ten autoimmune diseases are known to be associated with increased weight. So it’s critical to investigate obesity’s involvement in the pathology of such diseases.”

As well as their own research, Prof. Shoenfeld and his team from Tel Hashomer hospital conducted a systematic review of 329 studies from around the world on the relationship between obesity, adipokines (compounds secreted by fat tissue and involved in numerous physiological functions, including the immune response), and immune-related conditions like rheumatoid arthritis, multiple sclerosis, type-1 diabetes, psoriasis, inflammatory bowel disease, psoriatic arthritis, and Hashimoto thyroiditis.

Prof.Shoenfeld said according to their study and clinical and experimental data that reviewed, the involvement of adipokines in the pathogenesis of these autoimmune diseases is clear, “We were able to detail the metabolic and immunological activities of the main adipokines featured in the development and prognosis of several immune-related conditions.”

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